S tier peptides
- BPC-157
- A large body of research, mostly in rats, and positive reports; his main con was water retention.
- GHK-Cu
- Wide use, plenty of research and many forms, including skin care.
- Glutathione
- A tripeptide the body makes, which he calls the master antioxidant, with lots of research behind it.
- HCG (human chorionic gonadotropin)
- A long record in fertility medicine; he feels more people should know about it.
- HMG (human menopausal gonadotropin)
- His top fertility pick, since it supplies both FSH and LH activity.
- KPV
- Anti-inflammatory research in the gut and skin, and rising popularity; his con was that it is newer.
- NAD+
- A coenzyme in every cell, not a peptide, with lots of research and positive reports.
- Retatrutide
- Its three-receptor design and the large average weight reductions in its trials; his con was that it is new.
- Thymosin alpha-1
- What he calls an all-around immune peptide, with long clinical use outside the US and many human trials, with mixed results.
A tier peptides
- 5-Amino-1MQ
- A small molecule, not a peptide, rated for its NAD+ and metabolism effects in mice.
- ARA-290 (cibinetide)
- Nerve research that has reached small human trials; his con was its narrower focus.
- Cagrilintide
- Acts on appetite like GLP-1 drugs, but through amylin receptors; his con was that it is newer.
- Dihexa
- Reported in rat studies to support new connections between brain cells, though some people find it too much.
- Gonadorelin
- Prompts LH and FSH release in pulses for fertility; his cons were its short action and less research.
- Human growth hormone (HGH)
- A large body of research; his cons were its stigma and how often it is misused.
- IGF-1 LR3
- His top muscle-focused peptide, though it is potent and easy to misuse.
- Ipamorelin
- His top GHRP, which he values for a cleaner growth hormone pulse with less hunger, though mild.
- LL-37
- An immune and antimicrobial peptide the body makes, with small human wound trials so far, but potent, with side effects.
- Melanotan I
- His top tanning peptide, gentler and slower than Melanotan II.
- MOTS-c
- The most widely used mitochondrial peptide in his view, with positive reports.
- Oxytocin
- A well-researched hormone used in medicine, mainly in childbirth; he feels few people know about it.
- Selank
- His top anxiety-focused peptide, though not everyone notices it.
- Semaglutide
- Wide use and large trials, but he sees newer drugs in the class as stronger.
- Semax
- Brain performance research, held back by thinner research and mixed experiences.
- TB-500
- A widely used recovery peptide, though most of its research is on full-length thymosin beta-4.
- Tesamorelin
- His top GHRH analog, with large human trials behind it.
- Testosterone
- A steroid hormone, not a peptide, and one of the most studied; his cons were stigma, misuse and bad advice.
- Tirzepatide
- Wide use and large trials; like semaglutide, he placed it below retatrutide.
B tier peptides
- CJC-1295 with DAC
- Widely used and long acting, with more side effects when used incorrectly.
- DSIP (delta sleep-inducing peptide)
- The only sleep-focused peptide on his list, but results are hit or miss.
- Epithalon (Epitalon)
- A longevity bioregulator known for lab work on telomerase; experiences are hit or miss.
- Follistatin 315
- In his view one of the stronger muscle-focused peptides, as it binds myostatin; his con was more side effects.
- Follistatin 344
- In his view a stronger myostatin blocker than Follistatin 315, with the same side effect concern.
- FOXO4-DRI
- Studied in mice for clearing senescent cells, with few reported experiences.
- Fragment 176-191
- Rated above AOD-9604, but other peptides cover the same ground and more.
- GHRP-2
- A strong growth hormone releaser that also raises prolactin, with strong side effects.
- GHRP-6
- A strong growth hormone releaser that sharply raises hunger, which most people dislike.
- Hexarelin
- The most potent GHRP in his view, held back by side effects.
- Humanin
- A mitochondrial peptide of interest for longevity, with little research or use.
- IGF-1 DES
- More potent than IGF-1 in lab studies, but easy to misuse.
- Kisspeptin-10
- Acts at the top of the reproductive hormone system, but reported experiences are poor.
- Melanotan II
- Faster on skin color and affects sexual desire, but easier to misuse, with more side effects.
- OS-01
- Studied for senescent cells and used topically, but new, with little research.
- PE-22-28
- His top mood-focused peptide, fast acting in mouse studies, though the research is new.
- PEG-MGF
- Focused on muscle repair, but impractical to use.
- Pinealon
- A brain bioregulator he calls a strong spiritual peptide, with less research.
- PNC-27
- The first cancer-focused peptide he covers, studied mainly in lab work on cancer cells, and still new.
- PT-141 (bremelanotide)
- Acts on brain pathways of sexual desire, studied in women and men, with hit-or-miss experiences.
- Sermorelin
- A well-known GHRH analog with a long history, but its effect is mild.
- SLU-PP-332
- A small molecule, not a peptide, studied in mice as an exercise mimetic; new, with reported sleep problems.
- SS-31 (elamipretide)
- His top mitochondria-protecting peptide, though its effects are hard to feel.
- Tesofensine
- A small molecule, not a peptide, acting on brain chemistry and appetite, with less research.
- VIP (vasoactive intestinal peptide)
- Quickly widens blood vessels and relaxes smooth muscle, but is newer to most people.
C tier peptides
- AOD-9604
- Studied for fat metabolism, but reported experiences are poor, and a larger human trial showed little effect on weight.
- B7-33
- A relaxin-based peptide studied for fibrosis, with little research and a narrow focus.
- Bronchogen
- One of the few bioregulators aimed at the lungs, with less research and mixed experiences.
- Cardiogen
- One of the few bioregulators aimed at the heart, with less research and mixed experiences.
- Cartalax
- A bioregulator aimed at cartilage and joints, with less research and mixed experiences.
- Cortagen
- A bioregulator aimed at the nervous system, with less research and mixed experiences.
- FGL(L)
- Studied for new nerve cell growth, with little research behind it.
- Livagen
- A bioregulator aimed at the liver, with less research and mixed experiences.
- Ovagen
- A bioregulator aimed at ovarian tissue, with less research and mixed experiences.
- P21
- A milder brain-focused peptide with less research and a short history.
- Pancragen
- A bioregulator aimed at the pancreas, with less research and mixed experiences.
- Prostamax
- A bioregulator aimed at prostate tissue, with less research and mixed experiences.
- Testagen
- A bioregulator discussed for testosterone, with what he sees as a minor effect and less research.
- Thymagen
- A bioregulator aimed at the immune system, with less research and mixed experiences.
- Thymalin
- A bioregulator aimed at the thymus gland, with less research and mixed experiences.
- Vesilute
- A bioregulator aimed at the bladder and urethra, with less research and mixed experiences.
D tier peptides
- Chonluten
- An airway bioregulator he sees as too general, uncommon and little researched.
- GHRH
- Mirrors the body's own signal, but weak and rarely used.
- MOD-GRF 1-29
- Well researched and often paired with a GHRP, but weak on its own.
- Vesugen
- A broad blood vessel bioregulator with less research and mixed experiences.
- Vilon
- A general tissue bioregulator he sees as too broad, with less research.
F tier peptides
Matthew placed no peptides in F. The lowest tier he used in the video was D, for compounds he saw as weak on their own, too general or backed by little research. A low tier reflects his view of the research and experience behind a compound, not a finding that it is unsafe, and a high tier does not show that it works. Each library profile summarizes what the studies found.
