Peptides for weight loss and metabolism
GLP-1 drugs and other compounds researched for appetite, body weight and metabolism. Semaglutide is an approved medicine, retatrutide and cagrilintide are in clinical trials, and the rest have mostly early research.
For education and research only. Not medical advice, and not a recommendation to use anything.
5-Amino-1MQSmall molecule (NNMT inhibitor), not a peptide
AOD-9604Synthetic peptide, 16 amino acids (modified growth hormone fragment)
CagrilintideInvestigational synthetic peptide (long-acting amylin analog)
MOTS-cMitochondrial-derived peptide, 16 amino acids
RetatrutideInvestigational synthetic peptide (triple hormone receptor agonist)
SemaglutideModified GLP-1 peptide, 31 amino acids
SLU-PP-332Small molecule (ERR agonist), not a peptide
TesofensineInvestigational small molecule (monoamine reuptake inhibitor), not a peptideSide by side
What each one is and how much research is behind it.
| Name | What it is | Evidence so far | |
|---|---|---|---|
| 5-Amino-1MQ | Small molecule (NNMT inhibitor), not a peptide | Cell and mouse studies only; no published human trials | Dosage |
| AOD-9604 | Synthetic peptide, 16 amino acids (modified growth hormone fragment) | Positive animal data; human weight trials were disappointing | Dosage |
| Cagrilintide | Investigational synthetic peptide (long-acting amylin analog) | Phase 2 and 3 human trials, mostly combined with semaglutide | |
| MOTS-c | Mitochondrial-derived peptide, 16 amino acids | Mostly mouse studies; small observational human studies | Dosage |
| Retatrutide | Investigational synthetic peptide (triple hormone receptor agonist) | Phase 2 and phase 3 trial results; investigational as of 2026 | |
| Semaglutide | Modified GLP-1 peptide, 31 amino acids | Many large randomized human trials | |
| SLU-PP-332 | Small molecule (ERR agonist), not a peptide | Cell and mouse studies only; no human trials | Dosage |
| Tesofensine | Investigational small molecule (monoamine reuptake inhibitor), not a peptide | Phase 2 and some later human trials; investigational | Dosage |
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